Roemisch and colleagues found that about 9 % of a cohort of 140 normal donor plasmas had significant reduced pro-uPA activity while FSAP antigen levels were normal.

When FSAP was purified from such plasmas it displayed reduced pro-uPA activating activity, while Factor VII activating activity was normal.

In 1 % of the plasmas reduced activity levels as well as reduced antigen levels were found.

Authors and Source:
Roemisch et al., Bloood Coagul. Fibrinolysis 2001 July;12(5):375-383

Title:
Quantitation of the factor VII- and single-chain plasminogen activator-activating protease in plasmas of healthy subjects