FSAP was studied at the protein level (immuno-histochemistry) and the mRNA level (PCR) in atherosclerotic lesions obtained by directional coronary atheroectomy. Higher levels of FSAP mRNA (p<0,001) as well as FSAP antigen (p<0,005) were observed in patients with acute coronary syndromes compared to patients with stable angina pectoris. FSAP was also found to be co-localized with the macrophage-rich shoulder of the plaques. In vitro experiments indicated that monocyte-derived macrophages can express FSAP. Parahuleva and his colleagues concluded that FSAP may play a role in plaque destabilization.

Title:
Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques.

Authors and Source:
Parahuleva et al. Atherosclerosis. 2008 Jan;196(1):164-171.