In their “Northwick Park Heart Study II” Ireland and colleagues addressed the risk for coronary disease in a prospective study of cardiovascular disorders. They found an interactive effect upon risk between the FSAP G511E allele and elevated levels of cholesterol, triglyeride, or fibrinogen. This was taken to conclude that “…the FSAP G511E allele exacerbates atherosclerosis or its clinical sequelae.”

Title:
The factor VII activating protease G511E (Marburg) variant and cardiovascular risk.

Authors and Source:
Ireland et al., Thromb Haemost. 2004 Nov;92(5):986-992.