Hunfeld and colleagues describe the purification of a novel serine protease from human plasma. The molecule was termed “Plasma Hyaluronan Binding Serine Protease (PHBSP, HABP2)”. N-terminal sequencing revealed that it is a heparan-growth factor-like molecule.

Later, when its Factor VII activating activity had been detected, it was renamed to “Factor VII-Activating Protease (FSAP)”.

Authors and Source:
Hunfeld et al., FEBS Lett. 1999 Aug 6;456(2):290-294.

Title:
Detection of a novel plasma serine protease during purification of vitamin K-dependent coagulation factors.