Review on the possible role of FSAP in coagulation, fibrinolysis and atherothrombosis

In this 2003 editorial Mann discusses the biological role of FSAP. He points out that 1 % of total plasma factor VII is present in its cleaved enzymatically active form (VIIa) and that so far there is no adequate explanation for the source of this active enzyme. He suggests that “… FSAP is a leading candidate [...]

Tests for Factor VII-Activating Protease

Stephan and colleagues review and summarize information on different assays for FSAP and its Marburg I variant. This includes the measurement of antigen levels, pro-uPA and FVII activating activity, and genotype. Authors and Source: Stephan et al., Clin Chem Lab Med. 2008;46(8):1109-1116. Title: Tests for the measurement of factor VII-activating protease (FSAP) activity and antigen levels in citrated plasma, their [...]

Review on Factor VII-Activating Protease and Atherosclerosis

This is a current review on the role of FSAP in vascular biology, i.e. the “… contribution of FSAP to vascular fibroproliferative inflammatory diseases in the context of pericellular proteolysis of the extracellular matrix, growth factor activity and hemostasis …”. Authors and Source: Kanse et al., Thromb Haemost. 2008 Feb;99(2):286-289. Title: Factor VII-activating protease (FSAP): vascular functions and role [...]