In the following four publications, the pro-uPA activating activity and Factor VII activating activity of FSAP, as well as its auto-activation and activation by uPA was described.

Based on these activities a role of FSAP in the hemostatic system has been suggested.

Authors and Source:
Römisch et al., Blood Coagul Fibrinolysis. 1999 Dec;10(8):471-479
Title:
A protease isolated from human plasma activating factor VII independent of tissue factor.

Authors and Source:
Römisch et al., Haemostasis. 1999;29(5):292-299
Title:
The FVII activating protease cleaves single-chain plasminogen activators

Authors and Source:
Etscheid et al., Biol Chem. 2000 Dec;381(12):1223-1231
Title:
Activation of proPHBSP, the zymogen of a plasma hyaluronan binding serine protease, by an intermolecular autocatalytic mechanism

Authors and Source:
Kannemeier et al., J Biochem. 2001 Jul;268(13):3789-3796
Title:
Factor VII and single-chain plasminogen activator-activating protease: activation and autoactivation of the proenzyme